Single Responsibility Principle (SRP)says that "THERE SHOULD NEVER BE MORE THAN ONE REASON FOR A CLASS TO CHANGE.". Although this article mentions only about class, I think the SRP also applies to methods within the class: there should never be more than one reason for a method to change.
Visual Studio provides a good way to mark off section of file in the form of "region"so they can be collapsible and the code can be organized. Many people use region in a big method to organize the code. For example:
Note that not all people use regions like this. Many people use comments instead of regions in this kind of methods.
As you can see this is a clear violation of the single responsibility principle. The method does more than one thing: it validates the order data, create a top level order and create order items. This can certainly be put into separate method.
As you can see, wherever you are using "region" in your method to demarcate the code, you can very well put that code in a separate method.